Progast® Butyric Acid Complex

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Progast® Butyric Acid Complex is scientifically formulated to create a healthy environment for your good bacteria to thrive and at the same time prevent excess levels of bad bacteria from entering the blood stream.

The two primary ingredients in our Butyric Acid Complex are Butyrate and L-glutamine – both providing fuel for the epithelial cells of the intestines.

For most of us, treating the symptoms of digestive issues such as bloating or constipation, has become the new normal. We use over the counter heartburn medication, laxatives or take potent pre- and probiotic supplements with multiple strains.

What we are most likely dealing with is not the lack of good bacteria, but pathogens such as Gram-negative bacteria, viruses and worms that manage to cross the gut lining and penetrate the blood-brain barrier, causing life-threatening inflammation.

If you have dysbiosis (a disrupted gut microbiome) and gut problems, you have inflammation. If you have a protein rich diet and low stomach acid, and not enough enzymes, you have Intestinal permeability, or what we would prefer to refer to as ammonia permeability.

Resolving ammonia permeability, is one of the main steps in addressing inflammatory gut conditions. At the same time, we need to keep the gut lining healthy and the cells in the gut wall well supplied with nutrients such as butyrate and L-glutamine. Vitamin B6 synthesizes glutamine from glutamate and ammonia.

Butyric acid (also known as butyrate) is a short-chain fatty acids produced by probiotic fermentation of fibre and is the primary source of energy for the colon cells. Butyric acid production may be reduced in patients with, or who have had, an unbalanced and low-fibre diet, intestinal inflammation, antibiotic use, or bacterial microflora disturbances. Without butyrate, these cells in the colon (colonocytes) die.

Due to cross-talk between the gut and the brain, inflammation of the gut and brain are related. Butyric acid enhances our neuroplasticity and delays brain ageing conditions. Loss of neuroplasticity causes the trademark mental decline associated with Alzheimer’s and dementia. Thus, the microbiome produces essential molecules that we require in order to regulate our cognition, mood and behaviour. Ground-breaking treatments are using butyrate to treat neurodegenerative diseases, depression and cognitive impairment.

L-glutamine is the preferred energy source for the cells that line the small intestines. As an essential amino acid, L-glutamine may be depleted by certain pharmaceutical drugs, exhaustive exercise, during severe metabolic stress including surgery and inflammatory states. When the body is unable to produce enough L-glutamine to meet its needs, we need to supplement.

Exercise is recommended to reduce inflammation, and by taking L-glutamine, we can modulate the possible additional inflammatory response resulting from exercise.

We added L-glutamine to  Progast® Butyric Acid Complex as it plays an integral role in maintaining the health of the gastrointestinal tract as well as the immune system. Furtermore, L-glutamine ensures proper acid-base balance.

Progast® Butyric Acid Complex  helps to alleviate symptoms of abdominal discomfort, pain, cramps and intestinal spasms, bloating, flatulence, nausea, chronic constipation, heartburn and reflux.

Free from sugar, lactose, GMO, gluten and soya. No artificial additives, flavours, colourants or preservatives. Produced in an ISO 9001 facility.


Progast® Butyric Acid Complex is odour free, encapsulated in novel DRCaps® for maximum freshness and targeted release throughout your gastrointestinal (GI) tract. The novel DRCaps® protect the ingredients from degradation in the stomach by stomach acids and can also help mask taste and odor and reduce bad aftertaste without the addition of costly coatings.

DRcaps® capsules are innovative HPMC (hydroxypropylmethylcellulose) capsules. Owing to their plant-based origin, HPMC capsules are preferred over gelatine capsules by consumers pursuing a plant-based diet. HPMC capsules are also preferred for consumers wanting non-GMO and free-from delivery formats as they are free from preservatives, allergens, starch and gluten.

Certified Vegan, Non-GMO, Vegetarian Society, Halal and Kosher certifications.

*Source: DRCaps® Capsules Achieve Delayed Release Properties for Nutritional Ingredients in Human Clinical Study, 2014

Dosage and directions for use:

Take 1 capsule of Progast® Butyric Acid Complex daily, 30 min before a meal. The dosage can be increased to one capsule three times a day or as directed by your healthcare professional.

Adults and elderly: Take 1 to 3 capsules once a day
Children: Not recommended


Butyric Acid 300 mg
L-glutamine 200 mg
Magnesium Hydroxide 20 mg
Calcium Hydroxide 40 mg
Zinc Picolinate 25 mg
Copper AAC 0,25 mg

View Progast® Butyric Acid Complex Packaging Leaflet

Side effects and warnings:

Safety during pregnancy and lactation has not been established. Take under medical supervision if you are immune suppressed as butyric acid can cause systemic bacterial disease in such patients. Butyric acid is on the GRAS (Generally Recognized as Safe) list of the FDA. Vegan friendly, no GMO, dairy and gluten free. Produced in an ISO 9001 facility.

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  1. Heerdt BG, Houston MA, Augenlicht LH. Potentiation by specific short-chain fatty acids of differentiation and apoptosis in human colonic carcinoma cell lines. Cancer Res. 1994;54(12):3288-93.
  2. Krokowicz S., et al. Microencapsulated sodium butyrate administered to patients with diverticulosis decreases incidence of diverticulitis – a prospective randomized study. Int J Colorectal Dis, 2014:29, 387-393.
  3. Wang HB, Wang PY, Wang X, Wan YL, Liu YC. Butyrate enhances intestinal epithelial barrier function via up-regulation of tight junction protein Claudin-1 transcription. Dig Dis Sci. 2012;57(12):3126-3135.
  4. Cait, Alissa; Cardenas, Erick. Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization. Journal of Allergy and Clinical Immunology. 2019. 144(6):1638-1647.
  5. Vatanen, T., Franzosa, E.A., Schwager, R., et al. The human gut microbiome in early-onset type 1 diabetes from the TEDDY study. Nature. 2018. 562:589–594.

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